Analytical Data
-
基因名
CES2
- Application
-
别名
CES2；KIAA1740；Chromatin remodeling regulator CECR2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O00748
-
表达区间
27-559aa
-
氨基酸序列
QDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL
-
分子量
65.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CES2 (Carboxylesterase 2) is an important enzyme involved in the metabolism of various xenobiotics and endogenous compounds. It plays a crucial role in hydrolyzing and detoxifying a range of substrates, including drugs, environmental pollutants, and lipid metabolites. The study of CES2 has gained attention due to its potential implications in pharmacogenomics, drug metabolism, and the development of personalized medicine. Genetic variations in the CES2 gene can affect enzyme activity, leading to differences in drug efficacy and toxicity among individuals. In addition, CES2 has been implicated in the metabolism of prodrugs, which are inactive compounds that are converted into therapeutic agents by enzymatic action. Understanding CES2's structure and function can provide insights into its role in drug metabolism and help in designing more effective therapeutic strategies. Recent advancements in recombinant protein technology have enabled the production of purified CES2 for biochemical studies, allowing researchers to investigate its kinetic properties, substrate specificity, and interactions with inhibitors. Furthermore, the characterization of CES2 through structural studies using techniques like X-ray crystallography or cryo-electron microscopy can illuminate its catalytic mechanisms at the molecular level. Overall, the research on CES2 recombined protein is critical for elucidating its biological functions and potential applications in drug development, as well as in understanding inter-individual differences in drug response.
