Analytical Data
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Gene name
PEX11B
- Application
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Alternative Names
PEX11B; Peroxisomal membrane protein 11B; Peroxin-11B; Peroxisomal biogenesis factor 11B; Protein PEX11 homolog beta; PEX11-beta
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O96011
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Expression Region
1-259 aa
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AA Sequence
MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP
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Molecular Weight
54.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PEX11B is a member of the PEX11 family of peroxisomal biogenesis factors that play a crucial role in the regulation of peroxisome proliferation. Peroxisomes are essential organelles involved in various metabolic processes, including lipid metabolism and the detoxification of reactive oxygen species. Dysregulation of peroxisome dynamics has been linked to several human diseases, such as Zellweger syndrome and other peroxisomal biogenesis disorders. The study of PEX11B is particularly significant because it is involved in the fission of peroxisomes and has been implicated in the adaptive response of cells to metabolic stress. Understanding the molecular mechanisms underlying PEX11B function could provide insights into how peroxisome dynamics are altered in disease states and potentially reveal novel therapeutic targets. Recent research has focused on the structural and functional characterization of PEX11B, exploring its interactions with other proteins and its role in signaling pathways that regulate peroxisome biogenesis. The recombinant expression of PEX11B allows for in-depth biochemical studies, making it a valuable tool for elucidating its function and contributions to cellular homeostasis. This growing body of research underlines the importance of PEX11B in both fundamental cellular processes and its potential implications in health and disease.
