Analytical Data
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Gene name
PSMD8
- Application
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Alternative Names
PSMD8；26S proteasome non-ATPase regulatory subunit 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48556
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Expression Region
1-350aa
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AA Sequence
MFIKGRAPRA PPRERRRATR GGLRQVVAPP RALGSTSRPH FRRASVCRRR CRKSGGLLAA SRKMAAAAVN GAAGFSSSGP AATSGAVLQA ATGMYEQLKG EWNRKSPNLS KCGEELGRLK LVLLELNFLP TTGTKLTKQQ LILARDILEI GAQWSILRKD IPSFERYMAQ LKCYYFDYKE QLPESAYMHQ LLGLNLLFLL SQNRVAEFHT ELERLPAKDI QTNVYIKHPV SLEQYLMEGS YNKVFLAKGN IPAESYTFFI DILLDTIRDE IAGCIEKAYE KILFTEATRI LFFNTPKKMT DYAKKRGWVL GPNNYYSFAS QQQKPEDTTI PSTELAKQVI EYARQLEMIV
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Molecular Weight
39.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMD8, a pivotal component of the 26S proteasome, plays a crucial role in the regulation of protein degradation, which is essential for maintaining cellular homeostasis, regulating the cell cycle, and mediating various signaling pathways. Recent research has highlighted the significance of PSMD8 in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases, as alterations in its expression and activity can lead to dysfunctional protein degradation and accumulation of misfolded proteins. The study of recombinant PSMD8 protein is vital for understanding its structure-function relationships, mechanisms of action, and interaction with other proteasomal subunits. By producing recombinant PSMD8, researchers can examine its biochemical properties in vitro, explore its potential as a therapeutic target, and evaluate the effects of small molecules or peptides that may modulate its activity. Additionally, structural studies of recombinant PSMD8 can provide insights into the molecular mechanisms underlying its function within the proteasome and its impact on cellular processes. Overall, investigating PSMD8, especially in its recombinant form, is essential for elucidating its biological roles and developing potential therapeutic strategies to combat diseases associated with proteasome dysfunction.
