Analytical Data
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Gene name
PDSS1
- Application
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Alternative Names
PDSS1; DPS1; TPRTDecaprenyl-diphosphate synthase subunit 1; EC 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 1; Decaprenyl pyrophosphate synthase subunit 1; Trans-prenyltransferase 1; TPT 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5T2R2
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Expression Region
1-415 aa
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AA Sequence
MASRWWRWRR GCSWKPAARS PGPGSPGRAG PLGPSAAAEV RAQVHRRKGL DLSQIPYINL VKHLTSACPN VCRISRFHHT TPDSKTHSGE KYTDPFKLGW RDLKGLYEDI RKELLISTSE LKEMSEYYFD GKGKAFRPII VALMARACNI HHNNSRHVQA SQRAIALIAE MIHTASLVHD DVIDDASSRR GKHTVNKIWG EKKAVLAGDL ILSAASIALA RIGNTTVISI LTQVIEDLVR GEFLQLGSKE NENERFAHYL EKTFKKTASL IANSCKAVSV LGCPDPVVHE IAYQYGKNVG IAFQLIDDVL DFTSCSDQMG KPTSADLKLG LATGPVLFAC QQFPEMNAMI MRRFSLPGDV DRARQYVLQS DGVQQTTYLA QQYCHEAIRE ISKLRPSPER DALIQLSEIV LTRDK
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Molecular Weight
46.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PDSS1 (Prenyl Diphosphate Synthase Stimulation 1) is an essential enzyme responsible for the biosynthesis of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), which are critical precursors in the synthesis of various important biomolecules, including cholesterol, steroid hormones, and the non-canonical prenylation of proteins. Mutations in the PDSS1 gene are linked to several human disorders, primarily manifesting as growth retardation, skeletal abnormalities, and other developmental issues. The study of PDSS1 recombinant protein has garnered attention due to its potential implications in understanding these genetic diseases and its role in cellular signaling pathways. By investigating the enzymatic activities and structural characteristics of PDSS1, researchers aim to unravel the mechanistic basis of its function and regulation, which may provide insights into therapeutic strategies for PDSS1-related diseases. Furthermore, recombinant PDSS1 protein can serve as a valuable tool for drug discovery and the development of small molecule inhibitors that might target dysregulated biosynthetic pathways in various cancers and metabolic disorders. This field of research is rapidly evolving, and advancements in the understanding of PDSS1 function could lead to significant breakthroughs in biomedicine.
