Analytical Data
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基因名
PDSS1
- Application
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别名
PDSS1; DPS1; TPRTDecaprenyl-diphosphate synthase subunit 1; EC 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 1; Decaprenyl pyrophosphate synthase subunit 1; Trans-prenyltransferase 1; TPT 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T2R2
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表达区间
1-415 aa
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氨基酸序列
MASRWWRWRR GCSWKPAARS PGPGSPGRAG PLGPSAAAEV RAQVHRRKGL DLSQIPYINL VKHLTSACPN VCRISRFHHT TPDSKTHSGE KYTDPFKLGW RDLKGLYEDI RKELLISTSE LKEMSEYYFD GKGKAFRPII VALMARACNI HHNNSRHVQA SQRAIALIAE MIHTASLVHD DVIDDASSRR GKHTVNKIWG EKKAVLAGDL ILSAASIALA RIGNTTVISI LTQVIEDLVR GEFLQLGSKE NENERFAHYL EKTFKKTASL IANSCKAVSV LGCPDPVVHE IAYQYGKNVG IAFQLIDDVL DFTSCSDQMG KPTSADLKLG LATGPVLFAC QQFPEMNAMI MRRFSLPGDV DRARQYVLQS DGVQQTTYLA QQYCHEAIRE ISKLRPSPER DALIQLSEIV LTRDK
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分子量
46.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PDSS1 (Prenyl Diphosphate Synthase Stimulation 1) is an essential enzyme responsible for the biosynthesis of farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), which are critical precursors in the synthesis of various important biomolecules, including cholesterol, steroid hormones, and the non-canonical prenylation of proteins. Mutations in the PDSS1 gene are linked to several human disorders, primarily manifesting as growth retardation, skeletal abnormalities, and other developmental issues. The study of PDSS1 recombinant protein has garnered attention due to its potential implications in understanding these genetic diseases and its role in cellular signaling pathways. By investigating the enzymatic activities and structural characteristics of PDSS1, researchers aim to unravel the mechanistic basis of its function and regulation, which may provide insights into therapeutic strategies for PDSS1-related diseases. Furthermore, recombinant PDSS1 protein can serve as a valuable tool for drug discovery and the development of small molecule inhibitors that might target dysregulated biosynthetic pathways in various cancers and metabolic disorders. This field of research is rapidly evolving, and advancements in the understanding of PDSS1 function could lead to significant breakthroughs in biomedicine.
