Analytical Data
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Gene name
PDPN
- Application
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Alternative Names
Aggrus; Glycoprotein 36 KD; Glycoprotein 36; gp 36; GP 38; GP 40; gp36; GP38; GP40; HT1A 1; HT1A1; hT1alpha 1; hT1alpha 2; hT1alpha1; hT1alpha2; Lung type I cell membrane associated glycoprotein; Lung type I cell membrane associated glycoprotein isoform a; Lung type I cell membrane associated glycoprotein T1A 2; OTS 8; OTS8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; Pdpn; PDPN_HUMAN; Podoplanin; PSEC0003; PSEC0025; T1 alpha; T1 ALPHA GENE; T1-alpha; T1A 2; T1A; TI1A; TIA 2; TIA2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86YL7
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Expression Region
1-238 aa
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AA Sequence
MLTPLGKFSTAKFAVRLPRVWEARAPSLSGAPAPTPPAPPPSRSSRLGLWPRCFLIFPQLRILLLGPQESNNSTGTMWKVSALLFVLGSASLWVLAEGASTGQPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLPTSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAIGFIGGIIVVVMRKMSGRYSP
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Molecular Weight
51.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Podoplanin (PDPN) is a mucin-type glycoprotein predominantly expressed in lymphatic endothelial cells, fibroblastic reticular cells, and certain tumors. Its role in various biological processes, such as lymphatic development, tissue remodeling, and tumor metastasis, has garnered significant research interest. PDPN is known to interact with the C-type lectin receptor, CLEC-2, which plays a critical role in platelet activation and thrombus formation, further implicating PDPN in cardiovascular diseases and tumor biology. The engaging nature of PDPN in cell signaling, its contribution to the metastatic potential of cancer cells, and its differential expression in pathological conditions make it a promising target for therapeutic interventions. Moreover, PDPN has emerged as a valuable biomarker for specific cancers, including squamous cell carcinoma, highlighting its utility in diagnostic and prognostic applications. The recombinant expression of PDPN proteins in various systems facilitates in-depth studies of its structure-function relationships, interactions with other biomolecules, and potential as a drug target. Understanding the molecular mechanisms underlying PDPN’s activities and its role in disease contexts may pave the way for novel therapeutic strategies, including immunotherapy and targeted treatments. Hence, the research on PDPN recombinant proteins is crucial for elucidating their biological significance and exploring their potential uses in clinical applications.
