Analytical Data
-
基因名
PDPN
- Application
-
别名
Aggrus; Glycoprotein 36 KD; Glycoprotein 36; gp 36; GP 38; GP 40; gp36; GP38; GP40; HT1A 1; HT1A1; hT1alpha 1; hT1alpha 2; hT1alpha1; hT1alpha2; Lung type I cell membrane associated glycoprotein; Lung type I cell membrane associated glycoprotein isoform a; Lung type I cell membrane associated glycoprotein T1A 2; OTS 8; OTS8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; Pdpn; PDPN_HUMAN; Podoplanin; PSEC0003; PSEC0025; T1 alpha; T1 ALPHA GENE; T1-alpha; T1A 2; T1A; TI1A; TIA 2; TIA2
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q86YL7
-
表达区间
1-238 aa
-
氨基酸序列
MLTPLGKFSTAKFAVRLPRVWEARAPSLSGAPAPTPPAPPPSRSSRLGLWPRCFLIFPQLRILLLGPQESNNSTGTMWKVSALLFVLGSASLWVLAEGASTGQPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRYKSGLTTLVATSVNSVTGIRIEDLPTSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKDGLSTVTLVGIIVGVLLAIGFIGGIIVVVMRKMSGRYSP
-
分子量
51.3 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Podoplanin (PDPN) is a mucin-type glycoprotein predominantly expressed in lymphatic endothelial cells, fibroblastic reticular cells, and certain tumors. Its role in various biological processes, such as lymphatic development, tissue remodeling, and tumor metastasis, has garnered significant research interest. PDPN is known to interact with the C-type lectin receptor, CLEC-2, which plays a critical role in platelet activation and thrombus formation, further implicating PDPN in cardiovascular diseases and tumor biology. The engaging nature of PDPN in cell signaling, its contribution to the metastatic potential of cancer cells, and its differential expression in pathological conditions make it a promising target for therapeutic interventions. Moreover, PDPN has emerged as a valuable biomarker for specific cancers, including squamous cell carcinoma, highlighting its utility in diagnostic and prognostic applications. The recombinant expression of PDPN proteins in various systems facilitates in-depth studies of its structure-function relationships, interactions with other biomolecules, and potential as a drug target. Understanding the molecular mechanisms underlying PDPN’s activities and its role in disease contexts may pave the way for novel therapeutic strategies, including immunotherapy and targeted treatments. Hence, the research on PDPN recombinant proteins is crucial for elucidating their biological significance and exploring their potential uses in clinical applications.
