Analytical Data
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基因名
UCK1
- Application
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别名
UCK1；URK1；Uridine-cytidine kinase 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HA47
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表达区间
143-273aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMFYSQEIRDMFHLRLFVDTDSDVRLSRRVL RDVRRGRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAIN LIVQHIQDILNGDICKWHRGGSNGRSYKRTFSEPGDHPGMLTSGKRSHLE SS
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UCK1 (uridine-cytidine kinase 1) is an enzyme that plays a crucial role in nucleotide metabolism, specifically in the phosphorylation of uridine and cytidine to their corresponding mono-phosphates, which are essential for RNA synthesis and overall cellular function. Research on UCK1 has gained prominence due to its implications in various cellular processes and its potential as a therapeutic target in diseases such as cancer and neurodegenerative disorders. Abnormal expression or mutations of UCK1 have been associated with altered RNA metabolism, leading to impaired cellular proliferation and survival. Consequently, the recombinant production of UCK1 protein enables detailed studies of its structural and functional characteristics, which can provide insights into its enzymatic mechanisms and regulatory pathways. Understanding UCK1's role in cellular signaling and metabolic pathways could pave the way for the development of novel therapeutic strategies aimed at correcting the dysregulation of nucleotide metabolism in pathological conditions. Moreover, UCK1's potential as a biomarker for certain diseases emphasizes the importance of elucidating its biological functions through recombinant protein studies, facilitating further investigations into its role in health and disease.
