Analytical Data
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Gene name
CCR8
- Application
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Alternative Names
CCR8；CKRL1；CMKBR8；CMKBRL2；C-C chemokine receptor type 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51685
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Expression Region
1-355aa
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AA Sequence
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSL LGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWV FGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMG TTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNF KMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLF WVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSS VDYIL
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCR8 (C-C chemokine receptor type 8) is a G protein-coupled receptor that plays a crucial role in the immune system, particularly in the recruitment and migration of immune cells like T lymphocytes to sites of inflammation. It is primarily expressed in certain immune cell subsets, including regulatory T cells and Th2 cells, making it a significant player in allergic responses and in maintaining immune homeostasis. The upregulation of CCR8 has been associated with various diseases, including asthma, allergies, and certain cancers, highlighting its potential as a therapeutic target. Research on CCR8 recombinant proteins aims to elucidate its structure-function relationships and the molecular mechanisms underlying its role in immune responses. By generating and characterizing CCR8 recombinant proteins, scientists can better understand how this receptor interacts with its ligands, such as chemokines, and how these interactions influence cellular behavior. Furthermore, CCR8-targeted therapies, including monoclonal antibodies or small molecules, are being explored as innovative approaches to modulate immune responses in diseases characterized by dysregulated CCR8 activity. Thus, the study of CCR8 recombinant proteins is pivotal for the development of novel immunotherapies and for gaining insights into the complex dynamics of the immune system.
