Analytical Data
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Gene name
ARL4C
- Application
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Alternative Names
ADP ribosylation factor like 4C; ADP ribosylation factor like 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56559
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Expression Region
2-192aa
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AA Sequence
GNISSNISA FQSLHIVMLG LDSAGKTTVL YRLKFNEFVN TVPTIGFNTE KIKLSNGTAK GISCHFWDVG GQEKLRPLWK SYSRCTDGII YVVDSVDVDR LEEAKTELHK VTKFAENQGT PLLVIANKQD LPKSLPVAEI EKQLALHELI PATTYHVQPA CAIIGEGLTE GMDKLYEMIL KRRKSLKQKK KR
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Molecular Weight
21.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARL4C (ADP-ribosylation factor-like protein 4C) is a member of the ARF (ADP-ribosylation factor) family, which plays a crucial role in various cellular processes, including vesicle trafficking, cytoskeletal dynamics, and signaling pathways. The study of ARL4C is particularly significant due to its involvement in cell proliferation and differentiation, making it a potential target for therapeutic interventions in cancers and other diseases. Emerging research has highlighted ARL4C's role in modulating the actin cytoskeleton and its interactions with effector proteins, which can influence cellular migration and invasion. Furthermore, aberrations in ARL4C expression or activity have been linked to pathological conditions, raising interest in understanding its mechanistic functions at a molecular level. Recent advancements in biochemical techniques and structural biology have facilitated more detailed analyses of ARL4C, allowing researchers to elucidate its conformational dynamics and interactions within the cellular milieu. The ongoing investigation into ARL4C's role in various biological contexts holds promise for uncovering new avenues for drug development and potential biomarkers for disease progression. As research continues to unveil the complexities of ARL4C's functions, it becomes increasingly evident that this protein is not only vital for normal cellular homeostasis but also a key player in the pathogenesis of diseases, thus underscoring the importance of studying its recombinant protein for both basic science and clinical applications. Overall, the exploration of ARL4C's biochemical properties and biological significance presents an exciting frontier in molecular biology and medicine.
