Analytical Data
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基因名
TXN
- Application
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别名
TXN；KIAA1652；Thioredoxin reductase 2. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10599
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表达区间
1-105aa
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氨基酸序列
MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV
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分子量
12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TXN (thioredoxin) protein family plays an essential role in cellular redox regulation, influencing various biological processes, including protein folding, antioxidant defense, and cell signaling. Research into TXN has gained importance due to its implications in numerous diseases, such as cancer, neurodegeneration, and diabetes, where oxidative stress and disrupted redox balance are contributing factors. TXN proteins exhibit thiol-disulfide exchange activity, allowing them to act as pivotal antioxidants by reducing other proteins and maintaining cellular redox homeostasis. Recent studies have highlighted the potential of TXN as a therapeutic target, suggesting that TXN manipulation could offer new avenues for treatment. The ongoing investigation into TXN's structure, function, and regulatory mechanisms not only enhances our understanding of fundamental biological processes but also paves the way for innovative strategies in disease intervention, making TXN research a crucial topic in modern biochemical and medical science.
