Analytical Data
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Gene name
TXN
- Application
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Alternative Names
TXN;KIAA1652;Thioredoxin reductase 2. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10599
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Expression Region
1-105aa
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AA Sequence
MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV
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Molecular Weight
12 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The TXN (thioredoxin) protein family plays an essential role in cellular redox regulation, influencing various biological processes, including protein folding, antioxidant defense, and cell signaling. Research into TXN has gained importance due to its implications in numerous diseases, such as cancer, neurodegeneration, and diabetes, where oxidative stress and disrupted redox balance are contributing factors. TXN proteins exhibit thiol-disulfide exchange activity, allowing them to act as pivotal antioxidants by reducing other proteins and maintaining cellular redox homeostasis. Recent studies have highlighted the potential of TXN as a therapeutic target, suggesting that TXN manipulation could offer new avenues for treatment. The ongoing investigation into TXN's structure, function, and regulatory mechanisms not only enhances our understanding of fundamental biological processes but also paves the way for innovative strategies in disease intervention, making TXN research a crucial topic in modern biochemical and medical science.











