Analytical Data
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Gene name
PBX1
- Application
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Alternative Names
DKFZp686B09108; Homeo box protein PBX1; Homeo box protein PRL; Homeobox protein PBX 1; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; PBX 1; Pbx1; PBX1_HUMAN; Pre B cell leukemia homeobox 1; Pre B cell leukemia transcription factor 1; Pre-B-cell leukemia transcription factor 1; PRL
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40424
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Expression Region
1-430 aa
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AA Sequence
MDEQPRLMHS HAGVGMAGHP GLSQHLQDGA GGTEGEGGRK QDIGDILQQI MTITDQSLDE AQARKHALNC HRMKPALFNV LCEIKEKTVL SIRGAQEEEP TDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGAG SDNSVEHSDY RAKLSQIRQI YHTELEKYEQ ACNEFTTHVM NLLREQSRTR PISPKEIERM VSIIHRKFSS IQMQLKQSTC EAVMILRSRF LDARRKRRNF NKQATEILNE YFYSHLSNPY PSEEAKEELA KKCGITVSQV SNWFGNKRIR YKKNIGKFQE EANIYAAKTA VTATNVSAHG SQANSPSTPN SAGSSSSFNM SNSGDLFMSV QSLNGDSYQG AQVGANVQSQ VDTLRHVISQ TGGYSDGLAA SQMYSPQGIS ANGGWQDATT PSSVTSPTEG PGSVHSDTSN
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Molecular Weight
46.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PBX1 (Pre-B-Cell Leukemia Homeobox 1) is a critical transcription factor that plays a significant role in hematopoiesis and embryonic development. Abnormalities and rearrangements of the PBX1 gene have been implicated in various hematological malignancies, including pre-B-cell acute lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML). These rearrangements can result in the production of fusion proteins that alter normal cellular function and promote oncogenesis. Due to its role in regulating important target genes, PBX1 is not only a key player in normal cell differentiation but also a potential therapeutic target in cancers characterized by its dysregulation. Research on PBX1 recombinant proteins focuses on understanding the structural and functional implications of these rearrangements and exploring their therapeutic potential. By studying the interactions of PBX1 fusion proteins with other regulatory molecules, scientists aim to elucidate the mechanisms underlying their oncogenic properties. This knowledge could pave the way for developing novel therapeutic strategies that specifically target PBX1 aberrations, potentially improving outcomes for patients with PBX1-related malignancies. The exploration of PBX1 also enhances our understanding of basic biological processes such as gene regulation, cell fate determination, and the development of various tissue types. Overall, PBX1 and its recombinant proteins represent a significant frontier in cancer research, merging insights from molecular biology, genetics, and therapeutic innovation.
