Analytical Data
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Gene name
PATZ1
- Application
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Alternative Names
8430401L15Rik; AI447519; and zinc finger-containing protein 1; AT hook-; BTB POZ domain zinc finger transcription factor; BTB/POZ domain zinc finger transcription factor; dJ400N23; Mazr; PATZ ; PATZ1; PATZ1_HUMAN; POZ (BTB) and AT hook containing zinc finger 1; POZ . AT hook. and zinc finger containing protein 1; POZ-; Protein kinase A RI subunit alpha associated protein; Protein kinase A RI subunit alpha-associated protein; RIAZ; Transcription factor MAZR ; ZBTB19; Zfp278; Zinc finger and BTB domain containing protein 19 ; Zinc finger and BTB domain-containing protein 19; Zinc finger protein 278; Zinc finger protein 278. isoform CRA_d; Zinc finger sarcoma gene protein; ZNF278; ZSG
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HBE1
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Expression Region
1-687 aa
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AA Sequence
MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAALAANSN GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQTCNAS FATRDRLRSH LACHEDKVPC QVCGKYLRAA YMADHLKKHS EGPSNFCSIC NRGFSSASYL KVHVKTHHGV PLPQVSRHQE PILNGGAAFH CARTYGNKEG QKCSHQDPIE SSDSYGDLSD ASDLKTPEKQ SANGSFSCDM AVPKNKMESD GEKKYPCPEC GSFFRSKSYL NKHIQKVHVR ALGGPLGDLG PALGSPFSPQ QNMSLLESFG FQIVQSAFAS SLVDPEVDQQ PMGPEGK
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Molecular Weight
74.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PATZ1 (PATSZ1) is a transcription factor belonging to the POZ (Pox virus and Zinc finger) domain family, playing a critical role in various biological processes, including cell growth, differentiation, and apoptosis. Its involvement in the regulation of gene expression has sparked interest in understanding its functional mechanisms and potential implications in various diseases, particularly cancer. PATZ1 has been identified as a key player in the development of different tumor types, where its expression levels can influence tumor aggressiveness and patient prognosis. Recombinant PATZ1 protein studies facilitate the exploration of its structural and functional characteristics, uncovering its interactions with other proteins and DNA sequences. This research is vital for elucidating how PATZ1 contributes to oncogenic pathways and cellular homeostasis. Furthermore, understanding the protein's role may provide insights into novel therapeutic strategies aimed at targeting PATZ1-related signaling pathways or restoring its normal function in malignancies. Researchers often use techniques such as protein purification, functional assays, and structural biology methods to analyze PATZ1’s activity in cellular contexts, paving the way for potential clinical applications and advancements in cancer therapy. Thus, the study of recombinant PATZ1 not only enhances our comprehension of fundamental biological processes but also opens avenues for therapeutic innovations in treating PATZ1-associated diseases.
