Analytical Data
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基因名
CDK13
- Application
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别名
CDK13；CDC2L；CDC2L5；CHED；Cyclin-dependent kinase 13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14004
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表达区间
516-1512aa
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氨基酸序列
KKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVG KESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPM LPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSP EEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGT YGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSII NMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIK SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSE ESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQ ANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFV FIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQ DCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPS SQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLN IKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQT IQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEAS LQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPP EPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDP KREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLER RSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAG PMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGN LQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
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分子量
160 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK13 (Cyclin-Dependent Kinase 13) is a member of the cyclin-dependent kinase family, which plays a crucial role in regulating transcription and cell cycle progression. The study of CDK13 has gained prominence due to its involvement in various cellular processes, including RNA polymerase II transcription elongation and the phosphorylation of specific transcription factors. Recent research has highlighted the significance of CDK13 in several cancer types, where alterations in its expression or function are associated with tumorigenesis and poor prognosis. Additionally, CDK13 has been implicated in the regulation of splicing and mRNA processing, linking it to the broader landscape of gene expression control. Given its multifaceted roles, CDK13 has emerged as a potential therapeutic target. Efforts to understand its structure, interaction with cyclins, and regulatory mechanisms are critical for unraveling its contributions to both normal physiology and disease states. Investigating CDK13’s function at the molecular level could pave the way for novel interventions in cancer and other disorders linked to transcriptional misregulation.
