Analytical Data
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基因名
SOX11
- Application
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别名
SOX11；Transcription factor SOX-11
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35716
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表达区间
1-441aa
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氨基酸序列
MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP RKKPKMDPSA KPSASQSPEK SAAGGGGGSA GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA GAGKAAQSGD YGGAGDDYVL GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK QEPDEEDEEP PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS SGSSGEDADD LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD SFSEGSLGSH FEFPDYCTPE LSEMIAGDWL EANFSDLVFT Y
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分子量
46.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOX11 is a member of the SRY-related HMG-box (SOX) family of transcription factors, which play critical roles in development and cell fate determination. Research targeting SOX11 has gained significant attention due to its association with various malignancies, particularly in neuroblastoma and certain types of lymphomas, where it is often implicated as a key factor in tumorigenesis and disease progression. Studies have shown that SOX11 expression levels correlate with poor prognosis and aggressive disease features, making it a potential biomarker for clinical outcomes. Additionally, SOX11's involvement in regulating genes associated with neuronal differentiation and stem cell maintenance highlights its dual role in normal development and cancer. Characterizing the SOX11 recombinant protein has become essential for understanding its functional mechanisms, exploring its interactions with other biomolecules, and validating its role in oncogenic pathways. By producing and analyzing SOX11 recombinant protein, researchers aim to delineate its structural properties, investigate its binding affinities, and determine its regulatory effects on target genes. This research not only enhances our comprehension of SOX11's biological functions but also paves the way for developing targeted therapies that could inhibit its action in cancerous processes, ultimately contributing to more effective treatments for SOX11-associated malignancies.
