Analytical Data
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Gene name
PABPC5
- Application
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Alternative Names
PABPC5; PABP5; Polyadenylate-binding protein 5; PABP-5; Poly(A)-binding protein 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96DU9
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Expression Region
1-382 aa
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AA Sequence
MGSGEPNPAG KKKKYLKAAL YVGDLDPDVT EDMLYKKFRP AGPLRFTRIC RDPVTRSPLG YGYVNFRFPA DAEWALNTMN FDLINGKPFR LMWSQPDDRL RKSGVGNIFI KNLDKSIDNR ALFYLFSAFG NILSCKVVCD DNGSKGYAYV HFDSLAAANR AIWHMNGVRL NNRQVYVGRF KFPEERAAEV RTRDRATFTN VFVKNIGDDI DDEKLKELFC EYGPTESVKV IRDASGKSKG FGFVRYETHE AAQKAVLDLH GKSIDGKVLY VGRAQKKIER LAELRRRFER LRLKEKSRPP GVPIYIKNLD ETINDEKLKE EFSSFGSISR AKVMMEVGQG KGFGVVCFSS FEEATKAVDE MNGRIVGSKP LHVTLGQARR RC
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Molecular Weight
43.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PABPC5 (Poly(A)-Binding Protein Cytoplasmic 5) is a member of the poly(A)-binding protein family, which plays critical roles in mRNA metabolism, stability, and translation regulation. Understanding PABPC5 is particularly important because it is involved in the cellular response to stress and regulates the fate of mRNAs during various physiological processes. Recent studies have suggested that PABPC5 may have implications in cancer biology and other diseases, as its expression levels can influence tumor progression and the response to treatment. Given its significant role in cell biology, the development of recombinant protein for PABPC5 has become a focal point of research. The production of PABPC5 recombinant protein allows for detailed functional studies and structural analyses, facilitating insights into its interaction with RNA and other binding partners. Furthermore, investigating PABPC5's role in post-transcriptional regulation might reveal potential therapeutic targets or biomarkers for diseases where its dysregulation is implicated. Thus, the research on PABPC5 recombinant protein is driven by a need to understand its mechanistic functions, contributions to cellular processes, and potential as a therapeutic target in human health. This research not only aims to elucidate the fundamental biology of PABPC5 but also to explore its application in genomic medicine and therapeutic interventions.
