Analytical Data
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Gene name
PABPC3
- Application
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Alternative Names
PABP-3; PABP3; PABP3_HUMAN; PABPC3; PABPL3; Poly(A) binding protein 3; Poly(A)-binding protein 3; Polyadenylate binding protein 3; Polyadenylate-binding protein 3; RP11-165I9.5; Testis specific poly(A) binding protein ; Testis-specific poly(A)-binding protein; tPABP
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H361
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Expression Region
1-631 aa
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AA Sequence
MNPSTPSYPT ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RICRDLITSG SSNYAYVNFQ HTKDAEHALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFVKNLDKSI NNKALYDTVS AFGNILSCNV VCDENGSKGY GFVHFETHEA AERAIKKMNG MLLNGRKVFV GQFKSRKERE AELGARAKEF PNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRTF EQMKQDRITR YQVVNLYVKN LDDGIDDERL RKAFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT KPLYVALAQR KEERQAYLTN EYMQRMASVR AVPNQRAPPS GYFMTAVPQT QNHAAYYPPS QIARLRPSPR WTAQGARPHP FQNKPSAIRP GAPRVPFSTM RPASSQVPRV MSTQRVANTS TQTVGPRPAA AAAAAATPAV RTVPRYKYAA GVRNPQQHRN AQPQVTMQQL AVHVQGQETL TASRLASAPP QKQKQMLGER LFPLIQAMHP TLAGKITGML LEIDNSELLY MLESPESLRS KVDEAVAVLQ AHQAKEATQK AVNSATGVPT V
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Molecular Weight
70.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PABPC3, or Poly(A)-binding protein cytoplasmic 3, is a key regulator of mRNA stability, translation, and degradation in eukaryotic cells. It is known to bind to poly(A) tails of mRNA and is involved in various cellular processes, including the regulation of gene expression, cellular response to stress, and involvement in pathways related to development and differentiation. The study of recombinant PABPC3 protein has gained traction due to its critical role in these fundamental processes and its potential implications in various diseases, including cancer and neurodegenerative disorders. Given its importance in mRNA metabolism, researchers have focused on elucidating its structure-function relationships, post-translational modifications, and interactions with other cellular proteins. The production of recombinant PABPC3 enables detailed biochemical assays and structural studies, allowing scientists to explore its mechanisms of action and regulatory roles within the cell. Additionally, understanding PABPC3 can contribute to the development of novel therapeutic strategies aimed at modulating its function in disease contexts, highlighting its significance as a potential target for biomedical research.
