Analytical Data
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Gene name
ARHGAP28
- Application
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Alternative Names
ARHGAP28; KIAA1314; Rho GTPase-activating Protein 28; Rho-type GTPase-activating Protein 28
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P2N2
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Expression Region
1-545aa
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AA Sequence
MNELPRDTCGNHTNQLDGTKEERELPRVIKTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSDSVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVTEALKRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLNNQTKAKDILAKFQYENRILHWQRAALSFLNGKWVKKEREESTETNRSPKHVFLFTIGLDIST
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Molecular Weight
88.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGAP28, a member of the Rho GTPase-activating protein family, plays a crucial role in regulating various cellular processes, including cytoskeletal dynamics, cell migration, and signal transduction. The interest in ARHGAP28 has surged in recent years due to its potential involvement in pathological conditions such as cancer and neurological disorders, where aberrant regulation of Rho GTPases has been implicated. Several studies have highlighted its significant impact on the behavior of cancer cells, influencing their proliferation, migration, and invasion capabilities. Furthermore, ARHGAP28 has been shown to interact with different signaling pathways, suggesting that it may serve as a vital regulator in the context of cellular communication and response to external stimuli. The development of recombinant ARHGAP28 protein holds promise for elucidating its functional mechanisms and roles within various cellular contexts. By producing this protein in a controlled manner, researchers can conduct a more detailed analysis of its activity, interactions with other proteins, and its effects on cellular processes. Overall, the study of ARHGAP28 not only enhances our understanding of fundamental cellular biology but also opens avenues for therapeutic interventions targeting diseases associated with its dysregulation.
