Analytical Data
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Gene name
APOBEC3H
- Application
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Alternative Names
MALLTAETFR LQFNNKRRLR RPYYPRKALL CYQLTPQNGS TPTRGYFENK KKCHAEICFI NEIKSMGLDE TQCYQVTCYL TWSPCSSCAW ELVDFIKAHD HLNLGIFASR LYYHWCKPQQ KGLRLLCGSQ VPVEVMGFPK FADCWENFVD HEKPLSFNPY KMLEELDKNS RAIKRRLERI KIPGVRAQGR YMDILCDAEV
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6NTF7
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Expression Region
1-200aa
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AA Sequence
MALLTAETFR LQFNNKRRLR RPYYPRKALL CYQLTPQNGS TPTRGYFENK KKCHAEICFI NEIKSMGLDE TQCYQVTCYL TWSPCSSCAW ELVDFIKAHD HLNLGIFASR LYYHWCKPQQ KGLRLLCGSQ VPVEVMGFPK FADCWENFVD HEKPLSFNPY KMLEELDKNS RAIKRRLERI KIPGVRAQGR YMDILCDAEV
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Molecular Weight
23.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APOBEC3H is a member of the APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of proteins, which are primarily known for their ability to edit RNA and DNA, thereby playing crucial roles in immune defense against viral infections, particularly those involving retroviruses such as HIV. Research on APOBEC3H has gained significance due to its polymorphic nature and the functional variability it exhibits in different populations, which may influence susceptibility to infections and disease progression. This protein is found to possess cytidine deaminase activity, enabling it to induce mutations in viral genomes, thus hampering viral replication. However, its evolutionary dynamics, including its potential to facilitate viral escape through hypermutation, also present a double-edged sword. Understanding the mechanisms governing APOBEC3H function and its interaction with viruses is essential for developing antiviral strategies and could provide insights into the broader implications of host-pathogen interactions. As researchers continue to investigate its role, the recombinant expression of APOBEC3H protein becomes vital for elucidating its functional properties, structural characteristics, and possible therapeutic applications, offering a promising avenue to enhance our understanding of innate immunity and viral pathogenesis.
