Analytical Data
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Gene name
OCTN2
- Application
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Alternative Names
OCTN2；OCTN2；Organic cation/carnitine transporter 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O76082
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Expression Region
1-557aa
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AA Sequence
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF
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Molecular Weight
62.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
OCTN2, also known as the organic cation/carnitine transporter 2, is a crucial membrane protein involved in the transport of carnitine and various organic cations across cellular membranes. Mutations in the OCTN2 gene can lead to numerous health issues, including primary carnitine deficiency, which is characterized by a reduced capacity to transport carnitine. This deficiency can result in serious metabolic consequences, such as impaired fatty acid oxidation and subsequent energy production, especially in tissues that rely heavily on fatty acids, like muscle and heart. The study of OCTN2 is significant for understanding not only its physiological roles but also its potential involvement in pharmacokinetics, as it influences the absorption and distribution of therapeutic drugs. Given the implications of OCTN2 in metabolic disorders, researchers have focused on characterizing the protein's structure, function, and mechanisms. Recombinant OCTN2 proteins are often developed to facilitate these studies, aiding in the elucidation of transport mechanisms and guiding the development of therapeutic interventions for carnitine deficiency and other related disorders. The exploration of OCTN2's role in drug transport also holds promise for improving drug delivery strategies and optimizing personalized medicine approaches. Thus, the investigation of OCTN2 recombinant proteins offers vital insights into both fundamental biology and therapeutic applications, highlighting its importance in metabolic health and pharmacotherapy.
