Analytical Data
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Gene name
OSBPL1A
- Application
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Alternative Names
FLJ10217; ORP 1; ORP-1; ORP1; OSBL1_HUMAN; OSBP 8; OSBP L1; OSBP related protein 1; OSBP-related protein 1; OSBP8; OSBPL 1; OSBPL 1A; OSBPL 1B; OSBPL1; OSBPL1A; OSBPL1B; Oxysterol binding protein like 1A; Oxysterol binding protein like 1B; Oxysterol binding protein related protein 1; Oxysterol-binding protein-related protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXW6
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Expression Region
1-100 aa
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AA Sequence
MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMRDTPLHRAAFTGRKICSQGS
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Molecular Weight
37.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSBPL1A, or Oxysterol-binding protein-like 1A, is a member of the oxysterol-binding protein family, which plays a crucial role in lipid metabolism and cellular signaling. Recent studies have indicated that OSBPL1A is involved in regulating cholesterol homeostasis and has implications in various physiological processes, including cellular proliferation and apoptosis. Given its association with lipid transport and signaling, abnormalities in OSBPL1A expression or function have been linked to several pathological conditions, including metabolic disorders and cardiovascular diseases. Moreover, the protein's structure suggests that it may interact with phospholipids and sterols, influencing membrane dynamics and cellular responses to environmental changes. As such, producing recombinant OSBPL1A has become essential for in-depth functional studies, allowing researchers to investigate its specific roles within the cell and its potential as a therapeutic target. Understanding the biochemical pathways involving OSBPL1A can not only provide insights into the fundamental aspects of cell biology but also open new avenues for treating diseases associated with lipid imbalances. There is an increasing interest in developing OSBPL1A as a biomarker for disease progression in metabolic syndromes, making the study of its recombinant protein increasingly relevant in the field of biomedical research.
