Analytical Data
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Gene name
APOBEC2
- Application
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Alternative Names
APOBEC2C->U-editing enzyme APOBEC-2; EC 3.5.4.36; mRNA(cytosine(6666)) deaminase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y235
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Expression Region
1-224aa
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AA Sequence
MAQKEEAAVA TEAASQNGED LENLDDPEKL KELIELPPFE IVTGERLPAN FFKFQFRNVE YSSGRNKTFL CYVVEAQGKG GQVQASRGYL EDEHAAAHAE EAFFNTILPA FDPALRYNVT WYVSSSPCAA CADRIIKTLS KTKNLRLLIL VGRLFMWEEP EIQAALKKLK EAGCKLRIMK PQDFEYVWQN FVEQEEGESK AFQPWEDIQE NFLYYEEKLA DILK
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Molecular Weight
25.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APOBEC2, a member of the APOBEC family of cytidine deaminases, has garnered attention in recent years due to its potential roles in both innate immune responses and genomic stability. Initially identified for its involvement in the editing of RNA and DNA, APOBEC2 is primarily expressed in muscle tissues and has been implicated in muscle development and function. Its ability to catalyze the deamination of cytidine residues into uridine has garnered interest for its implications in viral defense, particularly in counteracting retroviral infections. However, unlike other family members like APOBEC3, which are well-studied for their antiretroviral activity, the precise mechanisms and biological functions of APOBEC2 remain less understood. Recent studies have explored its structure and enzymatic activity, revealing unique properties that may differentiate it from other APOBEC proteins. Furthermore, there is growing evidence suggesting that APOBEC2 might have roles beyond immunity, potentially influencing processes such as muscle differentiation and regeneration. Understanding the functions of APOBEC2 could provide insights into its evolutionary significance, potential therapeutic applications in muscle-related diseases, and broader implications in cancer biology, where aberrant expression of APOBEC enzymes is linked to mutagenesis. This research is crucial for elucidating the multifaceted roles of APOBEC proteins and their impact on cellular processes and disease mechanisms.
