Recombinant Human TNF-α Protein，His

Tumor Necrosis Factor-alpha (TNF-α) is a crucial cytokine involved in systemic inflammation and plays a significant role in the immune response. It is primarily produced by activated macrophages and has a variety of effects on cells, including the regulation of apoptosis, cell proliferation, and differentiation. Over the years, research has revealed its dual role in both promoting and inhibiting tumor growth, making it a target of interest in cancer therapy. Additionally, TNF-α is implicated in various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. The advent of recombinant DNA technology has enabled the production of TNF-α recombinant proteins, facilitating detailed studies on its structure and function, and allowing researchers to investigate its potential therapeutic applications. These recombinant proteins have been used in experimental settings to elucidate TNF-α's signaling pathways and to develop anti-inflammatory drugs and monoclonal antibodies. This research background underscores the importance of understanding TNF-α at a molecular level to harness its therapeutic potential while mitigating adverse effects associated with excessive inflammation and immune activation. As investigations continue, the development of TNF-α modulators may offer novel avenues for treating a range of diseases characterized by aberrant cytokine activity.