Analytical Data
-
Gene name
OSBPL2
- Application
-
Alternative Names
FLJ20223; KIAA0772; MGC4307; MGC8342; ORP-2; ORP2; OSBL2_HUMAN; OSBP related protein 2; OSBP-related protein 2; OSBPL2; Oxysterol binding protein like 2; Oxysterol binding protein related protein 2; Oxysterol-binding protein-related protein 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9H1P3
-
Expression Region
1-480 aa
-
AA Sequence
MNGEEEFFDA VTGFDSDNSS GEFSEANQKV TGMIDLDTSK NNRIGKTGER PSQENGIQKH RTSLPAPMFS RSDFSVWTIL KKCVGLELSK ITMPIAFNEP LSFLQRITEY MEHVYLIHRA SCQPQPLERM QSVAAFAVSA VASQWERTGK PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFHSEGL NHDFLFHGSI YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVIIGKLWIE QYGTVEILNH RTGHKCVLHF KPCGLFGKEL HKVEGHIQDK NKKKLFMIYG KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA QETVQVIPGS KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT DCRLRPDIRG MENGNMDLAS QEKERLEEKQ REARRERAKE EAEWQTRWFY PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY
-
Molecular Weight
55.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
OSBPL2 (Oxysterol-binding protein-like 2) is a member of the OSBP protein family that plays critical roles in lipid metabolism and cellular signaling. As research has progressed, it has become evident that OSBPL2 is implicated in various physiological processes, including cholesterol transport, regulation of membrane dynamics, and cellular responses to oxidative stress. The protein's ability to bind oxysterols, which are cholesterol derivatives with bioactive properties, suggests that OSBPL2 may have a significant impact on cellular cholesterol homeostasis and lipid metabolism. Additionally, alterations in OSBPL2 expression and function have been linked to various diseases, including metabolic disorders and cancer. The interest in OSBPL2 has heightened due to its potential role in mediating inter-organelle communication, particularly between the endoplasmic reticulum and lipid droplets, as well as its involvement in the regulation of inflammatory responses. Therefore, the study of OSBPL2 and its recombinantly expressed isoforms offers valuable insights into understanding the molecular mechanisms underlying these processes, which could pave the way for novel therapeutic strategies targeting metabolic and age-related diseases. Understanding the functional characteristics and interactions of OSBPL2 through recombinant protein studies can further elucidate its role in health and disease, making it a significant subject of research in the field of cell biology and molecular medicine.
