Analytical Data
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基因名
Bcl6B
- Application
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别名
Bcl6B；BAZF；ZNF62；B-cell CLL/lymphoma 6 member B Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N143
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表达区间
1-480aa
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氨基酸序列
MGSPAAPEGALGYVREFTRHSSDVLGNLNELRLRGILTDVTLLVGGQPLR AHKAVLIACSGFFYSIFRGRAGVGVDVLSLPGGPEARGFAPLLDFMYTSR LRLSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPLEAEPP TPPTAPPPGSPRRSEGHPDPPTESRSCSQGPPSPASPDPKACNWKKYKYI VLNSQASQAGSLVGERSSGQPCPQARLPSGDEASSSSSSSSSSSSEEGPI PGPQSRLSPTAATVQFKCGAPASTPYLLTSQAQDTSGSPSERARPLPGSE FFSCQNSEAVAGCSSGLDSLVPGDEDKPYKCQLCRSSFRYKGNLASHRTV HTGEKPYHCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHL RAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHF RHKSQLRLHLRQKHGAATNTKVHYHILGGP
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分子量
51.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Bcl6B, a member of the Bcl-6 family of proteins, plays a crucial role in various biological processes, including lymphocyte differentiation and immune responses. This protein functions primarily as a transcriptional repressor, regulating gene expression involved in cell proliferation and apoptosis. Research has shown that Bcl6B is implicated in several diseases, particularly lymphomas and autoimmune disorders. Its expression is often dysregulated in these conditions, suggesting a potential role as a biomarker or therapeutic target. Advances in recombinant protein technology have enabled the production of Bcl6B for functional studies, allowing researchers to investigate its interactions with other proteins and its effects on cellular pathways. Understanding the mechanistic role of Bcl6B in normal and pathological states is critical for developing novel strategies for disease intervention, making it a focal point of ongoing immunological and oncological research.
