Analytical Data
-
Gene name
CBLN2
- Application
-
Alternative Names
CBLN2；Cerebellin-2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8IUK8
-
Expression Region
52-224aa
-
AA Sequence
QNDTEPIVL EGKCLVVCDS SPSADGAVTS SLGISVRSGS AKVAFSATRS TNHEPSEMSN RTMTIYFDQV LVNIGNHFDL ASSIFVAPRK GIYSFSFHVV KVYNRQTIQV SLMQNGYPVI SAFAGDQDVT REAASNGVLL LMEREDKVHL KLERGNLMGG WKYSTFSGFL VFPL
-
Molecular Weight
24 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CBLN2, or Cerebellin-2, is a member of the CBLN family of proteins that play critical roles in synaptic function and neuronal communication in the central nervous system. Studies have shown that CBLN2 is involved in the modulation of synaptic transmission and plasticity, particularly in the cerebellum and hippocampus, regions essential for motor control and learning processes. Its interactions with other proteins, including receptors and adhesion molecules, suggest a significant role in the formation and maintenance of synapses. Dysregulation of CBLN2 has been implicated in various neurological disorders, including autism spectrum disorders, schizophrenia, and other cognitive impairments. The investigation of CBLN2 recombinant protein allows researchers to delve into its functional properties, elucidating pathways crucial for synaptogenesis and neuronal health. Through the expression and purification of CBLN2 recombinant proteins, scientists aim to better understand its molecular mechanisms, potential effects on neural circuit dynamics, and overall contributions to brain function. Moreover, the development of CBLN2-based therapeutic strategies could lead to innovative approaches for treating neurodevelopmental and neurodegenerative disorders, making this protein a significant focus within neuroscience research. Understanding the structure-function relationship of CBLN2 will pave the way for further advancements in neurobiological studies, potentially unlocking avenues for targeted interventions in related pathologies.
