Analytical Data
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基因名
CBLN2
- Application
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别名
CBLN2;Cerebellin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IUK8
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表达区间
52-224aa
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氨基酸序列
QNDTEPIVL EGKCLVVCDS SPSADGAVTS SLGISVRSGS AKVAFSATRS TNHEPSEMSN RTMTIYFDQV LVNIGNHFDL ASSIFVAPRK GIYSFSFHVV KVYNRQTIQV SLMQNGYPVI SAFAGDQDVT REAASNGVLL LMEREDKVHL KLERGNLMGG WKYSTFSGFL VFPL
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分子量
24 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBLN2, or Cerebellin-2, is a member of the CBLN family of proteins that play critical roles in synaptic function and neuronal communication in the central nervous system. Studies have shown that CBLN2 is involved in the modulation of synaptic transmission and plasticity, particularly in the cerebellum and hippocampus, regions essential for motor control and learning processes. Its interactions with other proteins, including receptors and adhesion molecules, suggest a significant role in the formation and maintenance of synapses. Dysregulation of CBLN2 has been implicated in various neurological disorders, including autism spectrum disorders, schizophrenia, and other cognitive impairments. The investigation of CBLN2 recombinant protein allows researchers to delve into its functional properties, elucidating pathways crucial for synaptogenesis and neuronal health. Through the expression and purification of CBLN2 recombinant proteins, scientists aim to better understand its molecular mechanisms, potential effects on neural circuit dynamics, and overall contributions to brain function. Moreover, the development of CBLN2-based therapeutic strategies could lead to innovative approaches for treating neurodevelopmental and neurodegenerative disorders, making this protein a significant focus within neuroscience research. Understanding the structure-function relationship of CBLN2 will pave the way for further advancements in neurobiological studies, potentially unlocking avenues for targeted interventions in related pathologies.












