Cat: PA2000-1424

Recombinant Human MAGEB16 Protein,His

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Analytical Data

  • Gene name

    MAGEB16

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    MAGEB16;Melanoma-associated antigen B16

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    A2A368

  • Expression Region

    1-324aa

  • AA Sequence

    MSQDQESPRC THDQHLQTFS ETQSLEVAQV SKALEKTLLS SSHPLVPGKL KEAPAAKAES PLEVPQSFCS SSIAVTTTSS SESDEASSNQ EEEDSPSSSE DTSDPRNVPA DALDQKVAFL VNFMLHKCQM KKPITKADML KIIIKDDESH FSEILLRASE HLEMIFGLDV VEVDPTTHCY GLFIKLGLTY DGMLSGEKGV PKTGLLIIVL GVIFMKGNRA TEEEVWEVLN LTGVYSGKKH FIFGEPRMLI TKDFVKEKYL EYQQVANSDP ARYEFLWGPR AKAETSKMKV LEFVAKVHGS YPHSFPSQYA EALKEEEERA RARI

  • Molecular Weight

    36.1 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

MAGEB16, a member of the MAGE (Melanoma Antigen Gene) family, has garnered significant attention in cancer research due to its potential role in tumor immunology and its expression profiles in various malignancies. Initially discovered in melanoma tissues, MAGE genes are known for their function in immune evasion, as they encode proteins that can interact with the immune system and contribute to the development of tumors. The study of MAGEB16 is particularly intriguing because it shows differential expression in several types of cancers, suggesting it may serve as a biomarker for disease diagnosis or prognosis. Furthermore, the recombinant protein form of MAGEB16 is being investigated for its potential use in immunotherapeutic strategies, such as cancer vaccines or adoptive cell therapy. Understanding the mechanisms by which MAGEB16 influences tumor growth and immune responses could offer new insights into targeted therapies. Additionally, due to its relatively restricted expression in normal tissues, MAGEB16 presents an attractive target for cancer immunotherapy, minimizing the risk of harming healthy cells. Consequently, ongoing research is focused on exploring the structural properties, immunogenicity, and cellular interactions of recombinant MAGEB16 proteins, aiming to leverage this knowledge for innovative cancer treatment modalities.

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