Analytical Data
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Gene name
TXNDC2
- Application
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Alternative Names
TXNDC2；SPTRX；Thioredoxin domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VQ3
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Expression Region
1-553aa
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AA Sequence
MDVDKELGME SVKAGASGKP EMRLGTQEET SEGDANESSL LVLSSNVPLL ALEFLEIAQA KEKAFLPMVS HTFHMRTEES DASQEGDDLP KSSANTSHPK QDDSPKSSEE TIQPKEGDIP KAPEETIQSK KEDLPKSSEK AIQPKESNIP KSSAKPIQPK LGNIPKASVK PSQPKEGDIP KAPEETIQSK KEDLPKSSEE AIQPKEGDIP KSSAKPIQPK LGNIAKTSVK PSQPKESDIP KSPEETIQPK EGDIPKSSAK PIQPKLGNIP KASVKPSQPK EGDISKSPEE AIQPKEGDLP KSLEEAIQPK EGDIPKSPEE AIQPKEGDIP KSLEEAIQPK EGDIPKSPEE TIQPKKGDIP KSPEEAIQPK EGDIPKSPKQ AIQPKEGDIP KSLEEAIPPK EIDIPKSPEE TIQPKEDDSP KSLEEATPSK EGDILKPEEE TMEFPEGDKV KVILSKEDFE ASLKEAGERL VAVDFSATWC GPCRTIRPFF HALSVKHEDV VFLEVDADNC EEVVRECAIM CVPTFQFYKK EEKVDELCGA LKEKLEAVIA ELK
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXNDC2 (Thioredoxin Domain Containing 2) is an intriguing protein that has garnered attention in the field of cellular biology due to its potential roles in various physiological and pathological processes. Initially discovered as part of a larger family of thioredoxin-like proteins, TXNDC2 is implicated in redox regulation, which is crucial for maintaining cellular homeostasis and responding to oxidative stress. Research has shown that TXNDC2 may participate in the regulation of protein folding and degradation, influencing cellular signaling pathways and stress responses. Deregulation of TXNDC2 expression has been linked to several diseases, including cancer and neurodegenerative disorders, prompting a deeper investigation into its functional roles and mechanisms. The recombinant expression of TXNDC2 in various model systems has facilitated studies aimed at deciphering its structure-function relationships, ultimately contributing to our understanding of its biological significance. Notably, the generation of TXNDC2 recombinant proteins allows researchers to explore their interactions with other cellular factors and examine their potential as therapeutic targets or biomarkers for disease progression. Overall, the study of TXNDC2 and its recombinant forms stands at the forefront of efforts to elucidate the complexities of redox biology and its implications for health and disease.
