Analytical Data
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Gene name
CHRM4
- Application
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Alternative Names
CHRM4；Muscarinic acetylcholine receptor M4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08173
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Expression Region
1-479aa
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AA Sequence
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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Molecular Weight
53 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CHRM4, also known as the muscarinic acetylcholine receptor 4, is a member of the G protein-coupled receptor (GPCR) family, which plays a critical role in various physiological functions, including neurotransmission, modulation of hormone secretion, and regulation of smooth muscle contraction. Research has shown that CHRM4 is involved in several neuropsychiatric disorders, such as schizophrenia and Parkinson's disease, as well as metabolic conditions. Given its significant involvement in these pathways, the characterization and study of CHRM4 recombinant proteins have garnered attention for potential therapeutic applications. By producing recombinant CHRM4, researchers can explore its structural and functional properties in detail, aiding in the identification of novel ligands and enhancing our understanding of its signaling mechanisms. Furthermore, the development of CHRM4 modulators could lead to innovative treatments addressing the dysregulation seen in related disorders. Overall, the investigation of CHRM4 recombinant proteins holds promise for advancing both basic science and clinical applications, paving the way for targeted drug development and improved patient outcomes.
