Analytical Data
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Gene name
TCP1
- Application
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Alternative Names
TCP1；CCT1；T-complex Protein 1 subunit alpha
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48643
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Expression Region
1-541aa
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AA Sequence
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRT SLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDD EIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDK ISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADME RRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKR SLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRA FADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTND MKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
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Molecular Weight
85 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCP1, or T-complex protein 1, is a key chaperonin that plays a crucial role in the proper folding of proteins within the cell. It belongs to a family of chaperonin proteins that assist in the assembly and refolding of non-native protein substrates under stress conditions. Research into TCP1 has gained significant attention due to its involvement in various cellular processes and its implications in protein misfolding diseases, such as neurodegenerative disorders. Understanding the mechanisms by which TCP1 facilitates protein folding can provide insights into the fundamental processes of cellular homeostasis and contribute to the development of therapeutic strategies for conditions associated with protein aggregation. Additionally, TCP1 has been shown to be essential for various cellular functions, including cell division, motility, and stress responses, thus making it a vital target for studies in cellular biology. Advances in biotechnology allow for the production of recombinant TCP1, enabling in-depth investigations into its structure, function, and interactions with other cellular components. This research is crucial for elucidating the potential roles of TCP1 in health and disease, paving the way for novel approaches in drug discovery and treatment strategies aimed at ameliorating conditions related to protein misfolding and aggregation.
