Analytical Data
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Gene name
SYT13
- Application
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Alternative Names
SYT13；KIAA1427；Synaptotagmin-13
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7L8C5
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Expression Region
30-426aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSCRHMHPK KGLLPRDQDP DLEKAKPSLL GSAQQFNVKK STEPVQPRAL LKFPDIYGPR PAVTAPEVIN YADYSLRSTE EPTAPASPQP PNDSRLKRQV TEELFILPQN GVVEDVCVME TWNPEKAASW NQAPKLHYCL DYDCQKAELF VTRLEAVTSN HDGGCDCYVQ GSVANRTGSV EAQTALKKRQ LHTTWEEGLV LPLAEEELPT ATLTLTLRTC DRFSRHSVAG ELRLGLDGTS VPLGAAQWGE LKTSAKEPSA GAGEVLLSIS YLPAANRLLV VLIKAKNLHS NQSKELLGKD VSVKVTLKHQ ARKLKKKQTK RAKHKINPVW NEMIMFELPD DLLQASSVEL EVLGQDDSGQ SCALGHCSLG LHTSGSERSH WEEMLKNPRR QIAMWHQLHL
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The SYT13 protein, a member of the synaptotagmin family, plays a pivotal role in synaptic vesicle exocytosis and neurotransmitter release, which are critical processes in neuronal communication. Emerging research has indicated that SYT13 is involved in various cellular functions beyond traditional synaptic activities, including endosomal trafficking and calcium signaling. This multifunctionality positions SYT13 as a potential key player in neurological disorders, where altered synaptic function contributes to pathophysiological conditions. Its structural characteristics, including the presence of multiple calcium-binding domains, suggest a unique mechanism of action that may modulate vesicle fusion and release. Given the increasing interest in understanding the molecular underpinnings of synaptic transmission, the recombinant production of SYT13 protein serves as a vital tool for dissecting its biological roles. By generating and characterizing SYT13 in vitro, researchers can explore its interaction with binding partners, elucidate its regulatory mechanisms, and investigate its potential implications in neurodegenerative diseases. This research avenue not only enhances our understanding of synaptic biology but also opens up possibilities for developing targeted therapies aimed at restoring synaptic function in affected individuals. Consequently, the study of SYT13 recombinant protein is poised to contribute significantly to the fields of neurobiology and therapeutic innovation.
