Analytical Data
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基因名
SUOX
- Application
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别名
SUOX；Sulfite oxidase. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51687
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表达区间
80-545aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSESTHIYTKEEVSSHTSPETGIWVTLGS EVFDVTEFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVRELLAQYK IGELNPEDKVAPTVETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTEN YITPNPIFFTRNHLPVPNLDPDTYRLHVVGAPGGQSLSLSLDDLHNFPRY EITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCDVLAQAG HQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQP LPRDHGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPS VDWETVDFDSAPSIQELPVQSAITEPRDGETVESGEVTIKGYAWSGGGRA VIRVDVSLDGGLTWQVAKLDGEEQRPRKAWAWRLWQLKAPVPAGQKELNI VCKAVDDGYNVQPDTVAPIWNLRGVLSNAW HRVHVYVSP
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分子量
54 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SUOX (sulfite oxidase) is a crucial enzyme in the human body that plays a significant role in the metabolism of sulfur-containing amino acids, specifically in the conversion of sulfite to sulfate, a process vital for the detoxification of sulfite. Deficiencies in SUOX can lead to sulfite accumulation, resulting in severe neurological disorders and other health issues. Research into SUOX has gained momentum due to the potential therapeutic implications for treating sulfite-related diseases, including sulfite oxidase deficiency, characterized by developmental delays and other neurological symptoms. Recombinant SUOX protein has been explored as a promising avenue for enzyme replacement therapy or as a tool for investigating the biochemical pathways involving sulfur metabolism. The production and characterization of recombinant SUOX allow researchers to study its kinetic properties, structure-function relationships, and interactions with various substrates and inhibitors. Enhanced understanding of SUOX functionality could pave the way for novel treatment strategies and contribute to our knowledge of related metabolic disorders, emphasizing the relevance of SUOX research in the fields of biochemistry and medicine. Furthermore, advancements in gene editing technologies and synthetic biology may further facilitate the development of SUOX-based therapies, potentially offering new hope for individuals affected by sulfite intolerances and related conditions.
