Analytical Data
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基因名
VRK2
- Application
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别名
VRK2；Serine/threonine-Protein kinase VRK2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86Y07
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表达区间
1-508aa
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氨基酸序列
MPPKRNEKYKLPIPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNRLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQKISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFTLSEETNADVYYYRIIIPVLLMLVFLALFFL
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分子量
58.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VRK2 (Vaccinia-related kinase 2) is a serine/threonine kinase belonging to the VRK family, which plays a crucial role in various cellular processes, including cell proliferation, apoptosis, and DNA damage response. Its dysregulation has been associated with several diseases, including cancer, where it is implicated in tumor progression and metastasis. Research has shown that VRK2 can modulate key signaling pathways and influence the activity of transcription factors, such as p53, thus impacting cell cycle regulation. The understanding of VRK2's structure and function is pivotal for elucidating its role in cellular mechanisms and disease pathogenesis. Recent studies have focused on the development of VRK2 recombinant proteins to explore its biochemical properties, interactions, and potential as a therapeutic target. By investigating the enzymatic activity and substrate specificity of VRK2, researchers aim to uncover novel insights into its functional dynamics and the broader implications for therapeutic interventions in related pathologies. The study of VRK2 not only enhances our understanding of kinase biology but also opens avenues for targeted therapies, providing a foundation for future clinical research in cancer and other diseases linked to VRK2 dysregulation.
