Analytical Data
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基因名
PNCK
- Application
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别名
PNCK；Calcium/calmodulin-dependent Protein kinase type 1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6P2M8
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表达区间
1-343aa
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氨基酸序列
MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA LRGKEALVEN EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS ESAKDFIRHL LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW
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分子量
38 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PNCK (p50nck) is a member of the non-receptor tyrosine kinase family and has garnered increasing attention due to its crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Research has shown that PNCK is involved in multiple signaling pathways, particularly those related to cancer and neurodegeneration, which positions it as a potential therapeutic target. The understanding of PNCK's function has been facilitated by advances in recombinant protein technology, allowing researchers to produce and purify PNCK in sufficient quantities for in vitro studies. By generating PNCK recombined proteins, scientists can investigate its structural properties and enzymatic activity, providing insights into its molecular mechanisms. Furthermore, the exploration of PNCK interactions with other proteins may reveal novel pathways that contribute to disease progression. Thus, the research surrounding recombinant PNCK not only aims to elucidate its fundamental biological roles but also to facilitate the development of targeted therapies for malignancies and neurological disorders associated with dysregulation of its signaling. The ongoing studies leverage sophisticated techniques including CRISPR, mass spectrometry, and cryo-electron microscopy, emphasizing the significance of PNCK in modern biomedical research. Through these efforts, the PNCK protein stands to offer valuable contributions to our comprehension of complex human diseases, paving the way for innovative treatment strategies.
