Analytical Data
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基因名
AKAP13
- Application
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别名
AKAP 13; AKAP Lbc; AKAP-13; AKAP-Lbc; AKAP13; AKP13_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12802
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表达区间
2-161aa
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氨基酸序列
KLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDA
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AKAP13, a member of the A-kinase anchoring protein family, plays a crucial role in cellular signaling by anchoring protein kinase A (PKA) to specific subcellular locations, thereby facilitating localized phosphorylation of target proteins. Its involvement in various physiological processes, including cardiac function, cell adhesion, and response to stress, makes it a significant focus of research. Dysregulation of AKAP13 has been implicated in several diseases, including cancer and heart disease, highlighting the importance of understanding its molecular mechanisms. The recombinant expression of AKAP13 allows researchers to investigate its structure-function relationship, explore its interactions with other signaling molecules, and assess its role in various cellular contexts. Studies utilizing recombinant AKAP13 can provide insights into its ability to modulate signaling pathways and contribute to the understanding of disease mechanisms, potentially leading to the development of targeted therapeutic strategies. Given the complexity of cellular signaling networks, dissecting the specific contributions of AKAP13 can enhance our knowledge of its function in health and disease and aid in the identification of novel biomarkers or therapeutic targets.
