Analytical Data
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Gene name
CPLX4
- Application
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Alternative Names
CPLX4；Complexin-4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z7G2
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Expression Region
1-157aa
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AA Sequence
MAFLMKSMIS NQVKNLGFGG GSEENKEEGG ASDPAAAQGM TREEYEEYQK QMIEEKMERD AAFTQKKAER ACLRVHLREK YRLPKSEMDE NQIQMAGDDV DLPEDLRKMV DEDQEEEEDK DSILGQIQNL QNMDLDTIKE KAQATFTEIK QTAEQKC
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Molecular Weight
18.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CPLX4, or Cortical Protein Complex 4, is a member of the complex protein family involved in various cellular processes, particularly in neurobiology. Recent studies suggest that CPLX4 plays a crucial role in synaptic function and neuronal communication, influencing neurotransmitter release and synaptic plasticity. Dysregulation of CPLX4 has been associated with neurological disorders, including autism spectrum disorders and schizophrenia, highlighting its significance in neurodevelopmental pathways. The research surrounding CPLX4 recombinant proteins aims to elucidate its structure-function relationship, investigate its interactions with other synaptic proteins, and dissect its role in learning and memory processes. By generating recombinant CPLX4 proteins, scientists can perform extensive biochemical assays and cellular experiments to understand its mechanism of action in synapses, paving the way for potential therapeutic strategies targeting CPLX4-related pathologies. The ongoing research underscores the importance of CPLX4 in the broader context of synaptic health and disease, offering insights into the molecular underpinnings of brain function and the potential for intervention in neurodegenerative conditions.
