Analytical Data
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基因名
AGPAT3
- Application
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别名
AGPAT3; LPAAT3; UNQ759/PRO1490; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; 1-acylglycerol-3-phosphate
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NRZ7
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表达区间
1-43.3aa
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氨基酸序列
MGSPAHLPKDAIAVFIVFPRVRHWLSGTRRQCTRRAPYVRCFKVPVLRKRSLVEEMSAEQITK
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分子量
33.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AGPAT3, or 1-Acylglycerol-3-Phosphate O-acyltransferase 3, is a crucial enzyme involved in lipid metabolism, particularly in the biosynthesis of glycerolipids. It catalyzes the acylation of lysophosphatidic acid to produce phosphatidic acid, a key precursor for the formation of triglycerides and phospholipids, thereby playing a significant role in cell membrane formation and energy storage. Recent studies have indicated that AGPAT3 is associated with various metabolic disorders, including obesity and insulin resistance, as it is implicated in the regulation of lipid accumulation in adipose tissue. Furthermore, its dysfunction has been linked to certain genetic conditions affecting lipid storage and utilization. Given the increasing prevalence of metabolic diseases worldwide, understanding the molecular mechanisms underlying AGPAT3’s function and regulation has become imperative. Researchers are focusing on characterizing AGPAT3 at the molecular level, assessing its activity and interaction with other metabolic pathways, and exploring its potential as a therapeutic target for ameliorating lipid-related disorders. This research not only aims to elucidate the enzyme's role in health and disease but also seeks to identify novel strategies for the management of metabolic syndrome through the modulation of AGPAT3 activity.
