Analytical Data
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Gene name
IREM2
- Application
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Alternative Names
IREM2；CD300LE；CLM2；CMRF35A5；CMRF35-like molecule 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q496F6
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Expression Region
1-205aa
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AA Sequence
MWLLPALLLLCLSGCLSLKGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCESIVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSYWCKIQTVWVLDSWSRDPSDLVRVYVSPAITTPRRTTHPATPPIFLVVNPGRNLSTGEVLTQNSGFRLSSPHFLLVVLLKLPLLLSMLGAVFWVNRPQWAPPGR
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Molecular Weight
22.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IREM2, or Immunoglobulin Receptor Expression Modulator 2, is a protein that plays a critical role in the immune response by regulating the activation and signaling of immune cells such as T and B lymphocytes. It has garnered attention in the field of immunology due to its involvement in modulating receptor expression and function, which can impact autoimmunity and allergic responses. Studies have shown that variations in IREM2 expression can influence disease susceptibility and severity, particularly in conditions like multiple sclerosis and asthma. Researchers are interested in understanding the structural and functional characteristics of IREM2 to explore its potential as a therapeutic target. By investigating its interactions with various immune receptors and signaling pathways, scientists aim to unveil mechanisms that could lead to innovative strategies for treating immune-related disorders. The exploration of IREM2's role in immune modulation not only contributes to fundamental immunological knowledge but also holds promise for the development of novel immunotherapies that can enhance or inhibit immune responses as needed.
