Analytical Data
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基因名
INSM2
- Application
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别名
INSM2；IA6；Insulinoma-associated Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96T92
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表达区间
1-566aa
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氨基酸序列
MPRGFLVKRT KRTGGLYRVR LAERVFPLLG PQGAPPFLEE APSASLPGAE RATPPTREEP GKGLTAEAAR EQSGSPCRAA GVSPGTGGRE GAEWRAGGRE GPGPSPSPSP SPAKPAGAEL RRAFLERCLS SPVSAESFPG GAAAVAAFSC SVAPAAAPTP GEQFLLPLRA PFPEPALQPD PAPLSAALQS LKRAAGGERR GKAPTDCASG PAAAGIKKPK AMRKLSFADE VTTSPVLGLK IKEEEPGAPS RGLGGSRTPL GEFICQLCKE QYADPFALAQ HRCSRIVRVE YRCPECDKVF SCPANLASHR RWHKPRPAAA NAATVSSADG KPPSSSSSSS RDSGAIASFL AEGKENSRIE RTADQHPQAR DSSGADQHPD SAPRQGLQVL THPEPPLPQG PYTEGVLGRR VPVPGSTSGG RGSEIFVCPY CHKKFRRQAY LRKHLSTHEA GSARALAPGF GSERGAPLAF ACPLCGAHFP TADIREKHRL WHAVREELLL PALAGAPPET SGPSGPSDGS AQQIFSCKHC PSTFFSSPGL TRHINKCHPS ESRQVLLLQM PLRPGC
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分子量
59.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INSM2 (Insulinoma-Associated Protein 2) is a transcription factor primarily involved in neuroendocrine differentiation and function. Research into recombinant INSM2 protein has gained momentum due to its potential roles in neuroendocrine tumors, diabetes, and other metabolic disorders. Elevated INSM2 expression is often observed in neuroendocrine tumors such as insulinomas and carcinoids, suggesting its importance as a biomarker for diagnosis and prognosis. The recombinant form of INSM2 allows researchers to investigate its molecular mechanisms, interactions with other proteins, and effects in cellular contexts. Furthermore, understanding the structure-function relationship of INSM2 through recombinant protein studies can uncover its role in cellular signaling pathways and potential therapeutic applications. Given the increasing incidence of neuroendocrine tumors and the need for novel diagnostic and therapeutic strategies, the study of INSM2 is critical. This research not only enhances our understanding of tumor biology but also opens avenues for targeted therapies that could improve treatment outcomes for patients with neuroendocrine cancers. Additionally, the exploration of INSM2 in other contexts, such as metabolic regulation, further underscores its significance in biomedical research. Thus, investigations into the recombinant INSM2 protein are vital for elucidating its multifaceted roles in health and disease.
