Analytical Data
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基因名
AGAP2
- Application
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别名
AGAP-2; Agap2; Agap2 ArfGAP with GTPase domain; ankyrin repeat and PH domain 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99490
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表达区间
1-836aa
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氨基酸序列
MHAQRQFVVAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV
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分子量
116.9 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AGAP2, or ArfGAP with GTPase-activating protein 2, is a member of the ArfGAP family that plays a critical role in regulating intracellular trafficking and membrane dynamics. Its function is contingent upon its ability to modulate the activity of Arf proteins, which are essential for vesicle formation and transport within cells. Research on AGAP2 has gained attention due to its involvement in various cellular processes, including endocytosis, exocytosis, and the recycling of membrane proteins, making it a key player in maintaining cellular homeostasis. Notably, AGAP2 has also been implicated in several pathological conditions, including cancer, where it may affect tumor progression and metastasis. The recombinant AGAP2 protein is studied to elucidate its structural and functional properties, enabling researchers to explore the mechanisms through which it influences cellular pathways. By producing and characterizing AGAP2 in a recombinant form, scientists aim to investigate its interactions with Arf proteins and other cellular factors, thereby enhancing our understanding of its role in health and disease. Furthermore, insights gained from AGAP2 research may pave the way for developing therapeutic strategies targeting its pathways, contributing to innovative approaches in combating diseases associated with dysregulated cellular trafficking. Overall, the study of recombinant AGAP2 not only enriches our understanding of fundamental biological processes but also holds potential clinical significance in the context of disease treatment and prevention.
