Analytical Data
-
基因名
CYP4F2
- Application
-
别名
CYP4F2；Cytochrome P450 4F2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P78329
-
表达区间
5-520aa
-
氨基酸序列
SLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQ GMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFF YSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASE GSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHID FLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL SKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD REPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISV FGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLAL TLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
-
分子量
59.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CYP4F2, a member of the cytochrome P450 family, is a key enzyme involved in the metabolism of various endogenous and exogenous substances, including fatty acids, steroids, and drugs. Its role in the metabolism of vitamin K and anticoagulant drugs, such as warfarin, underscores its clinical significance, as genetic variations in the CYP4F2 gene can influence individual responses to these medications. Studies have demonstrated that polymorphisms in the CYP4F2 gene can lead to altered enzyme activity and subsequently affect drug efficacy and safety. Consequently, research into the recombinant CYP4F2 protein has gained momentum, with efforts focused on understanding its structure, function, and interaction with substrates and inhibitors. Characterizing the recombinant CYP4F2 protein is crucial for elucidating its metabolic pathways and for developing personalized medicine approaches to optimize drug dosing and minimize adverse effects. Furthermore, insights gained from this research can contribute to better therapeutic strategies for managing conditions that require anticoagulation therapy, ultimately enhancing patient outcomes.
