Analytical Data
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基因名
ADCK4
- Application
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别名
COQ8B; ADCK4; Atypical kinase COQ8B. mitochondrial; AarF domain-containing Protein kinase 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96D53
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表达区间
1-544aa
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氨基酸序列
MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRYWASRQPDAATAGSLPTKGDSWVDPS
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADCK4 (akin to cyclic nucleotide phosphodiesterases and adenylyl cyclases) is a member of a family of proteins involved in mitochondrial function and metabolism, particularly in the context of coenzyme Q10 (CoQ10) biosynthesis. Mutations in the ADCK4 gene have been linked to a range of disorders, notably the autosomal recessive cerebellar ataxia associated with CoQ10 deficiency, which highlights its crucial role in cellular energy production and oxidative stress management. Research has shown that the ADCK4 protein is essential for the proper functioning of mitochondrial respiratory chain complexes, making it vital for ATP synthesis and cellular health. Given its role in CoQ10 synthesis, further investigations into the biochemical pathways involving ADCK4 could provide critical insights into mitochondrial dysfunction-related diseases. Additionally, the development of ADCK4 recombinant protein is significant for studying its functional properties, elucidating its interactions with other metabolic pathways, and exploring potential therapeutic interventions for conditions associated with ADCK4 deficiencies. Understanding the structure and function of ADCK4 at a molecular level may pave the way for innovative strategies to treat or manage diseases linked to mitochondrial dysfunction, thereby contributing to advancements in precision medicine and targeted therapies.
