Analytical Data
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Gene name
SORBS3
- Application
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Alternative Names
SORBS3;SCAM1;Vinexin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60504-2
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Expression Region
1-329aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMADGGSP FLGRRDFVYP SSTRDPSASN GGGSPARREE KKRKAARLKF DFQAQSPKEL TLQKGDIVYI HKEVDKNWLE GEHHGRLGIF PANYVEVLPA DEIPKPIKPP TYQVLEYGEA VAQYTFKGDL EVELSFRKGE HICLIRKVNE NWYEGRITGT GRQGIFPASY VQVSREPRLR LCDDGPQLPT SPRLTAAARS ARHPSSPSAL RSPADPIDLG GQTSPRRTGF SFPTQEPRPQ TQNLGTPGPA LSHSRGPSHP LDLGTSSPNT SQIHWTPYRA MYQYRPQNED ELELREGDRV DVMQQCDDGW FVGVSRRTQK FGTFPGNYVA PV
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Molecular Weight
39 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SORBS3 (Sorbin and SH3 Domain Containing 3) is a member of the SORBS family of scaffolding proteins that play essential roles in cellular signaling and cytoskeletal organization. It is notably involved in various physiological processes, including insulin signaling, and has been implicated in metabolic disorders and obesity. The study of SORBS3 is particularly significant due to its association with the regulation of glucose homeostasis and its potential as a therapeutic target in Type 2 diabetes. Research has shown that SORBS3 interacts with key signaling molecules, such as insulin receptor substrates, which are critical for insulin action in target tissues. Moreover, alterations in SORBS3 expression and function have been linked to the pathogenesis of metabolic diseases, making it a focal point for understanding the molecular mechanisms underlying these conditions. The exploration of SORBS3 through recombinant protein studies allows for a deeper investigation into its structural characteristics, interactions, and functional implications, paving the way to identify novel intervention strategies for metabolic dysfunctions. As a subject of ongoing research, SORBS3 represents a promising avenue for advancing our understanding of metabolic regulation and developing innovative therapeutic approaches.
