Analytical Data
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基因名
AP1s1
- Application
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别名
AP1s1；AP19；CLAPS1；AP-1 complex subunit sigma-1A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P61966
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表达区间
1-158aa
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氨基酸序列
MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL EWRDLKVVYK RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE LDIIFNFEKA YFILDEFLMG GDVQDTSKKS VLKAIEQADL LQEEDESPRS VLEEMGLA
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分子量
18.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP1s1, or adaptor protein complex 1 sigma 1 subunit, is a critical component of the clathrin-coated vesicle transport machinery, playing a vital role in intracellular trafficking and the sorting of proteins within the cell. The study of AP1s1 is particularly significant due to its involvement in various cellular processes, including endocytosis and exocytosis, which are essential for maintaining cellular homeostasis and communication. Disruptions or mutations in the AP1s1 gene have been linked to several diseases, including neurodegenerative disorders and certain types of cancer, highlighting its importance in health and disease. Research into AP1s1 has expanded our understanding of vesicular transport mechanisms, and this protein serves as a potential target for therapeutic interventions aimed at correcting trafficking errors that lead to pathological conditions. Recent advancements in structural biology and molecular genetics have propelled the exploration of AP1s1's function and regulation, providing insights into its role in the assembly of protein complexes involved in membrane dynamics. This line of research is essential for developing novel strategies to address diseases stemming from dysfunctional cellular transport systems. Understanding AP1s1's structure-function relationship could pave the way for innovative treatments that leverage the protein's pathways, ultimately contributing to advancements in biomedical research and therapeutic development.
