Analytical Data
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Gene name
NUPL1
- Application
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Alternative Names
NUP58; KIAA0410; NUPL1; Nucleoporin p58/p45; 58 kDa nucleoporin; Nucleoporin-like protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVL2
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Expression Region
1-599 aa
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AA Sequence
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT TSAATTGFSL GFNKPAASAT PFALPITSTS ASGLTLSSAL TSTPAASTGF TLNNLGGTTA TTTTASTGLS LGGALAGLGG SLFQSTNTGT SGLGQNALGL TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK ALKDENLPPV ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV QQFEVQLQQY RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA AQLQSIHENV KVLKEQYLGY RKMFLGDAVD VFETRRAEAK KWQNTPRVTT GPTPFSTMPN AAAVAMAATL TQQQQPATGP QPSLGVSFGT PFGSGIGTGL QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS LSAGFGSSST SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
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Molecular Weight
60.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUPL1 (Nuclear Pore Complex-Associated Protein 1) is a crucial nuclear protein that has garnered significant attention in the field of molecular biology due to its role in nucleocytoplasmic transport and involvement in various cellular processes. Research indicates that NUPL1 interacts with components of the nuclear pore complex, facilitating the transport of proteins and RNA between the nucleus and cytoplasm. Abnormalities in NUPL1 function have been implicated in several pathological conditions, including cancer, neurodegenerative diseases, and viral infections, making it a target of interest for therapeutic interventions. The generation of recombinant NUPL1 protein has enabled researchers to elucidate its structure-function relationships and examine its interactions with other cellular molecules in vitro. By expressing and purifying NUPL1, scientists aim to explore its molecular mechanisms, its role in disease states, and to identify potential drug targets that could mitigate the adverse effects of NUPL1 dysregulation. Such studies contribute to a deeper understanding of the nuclear transport system and its implications in health and disease, ultimately paving the way for innovative approaches in biotechnology and medicine.
