Analytical Data
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Gene name
NXF2
- Application
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Alternative Names
NXF2；TAPL2；NXF2B；Nuclear RNA export factor 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9GZY0
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Expression Region
1-626aa
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AA Sequence
MCSTLKKCGT YRTEVAECHD HGSTFQGRKK GGSSFRDNFD KRSCHYEHGG YERPPSHCQE NDGSVEMRDV HKDQQLRHTP YSIRCERRMK WHSEDEIRIT TWRNRKPPER KMSQNTQDGY TRNWFKVTIP YGIKYDKAWL MNSIQSHCSD RFTPVDFHYV RNRACFFVQD ASAASALKDV SYKIYDDENQ KICIFVNHST APYSVKNKLK PGQMEMLKLT MNKRYNVSQQ ALDLQNLRFD PDLMGRDIDI ILNRRNCMAA TLKIIERNFP ELLSLNLCNN KLYQLDGLSD ITEKAPKVKT LNLSKNKLES AWELGKVKGL KLEELWLEGN PLCSTFSDQS AYVSAIRDCF PKLLRLDGRE LSAPVIVDID SSETMKPCKE NFTGSETLKH LVLQFLQQYY SIYDSGDRQG LLGAYHDEAC FSLAIPFDPK DSAPSSLCKY FEDSRNMKTL KDPYLKGELL RRTKRDIVDS LSALPKTQHD LSSILVDVWC QTERMLCFSV NGVFKEVEGQ SQGSVLAFTR TFIATPGSSS SLCIVNDELF VRDASPQETQ SAFSIPVSTL SSSSEPSLSQ EQQEMVQAFS AQSGMKLEWS QKCLQDNEWN YTRAGQAFTM LQTEGKIPAE AFKQIS
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Molecular Weight
71.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NXF2 (Nuclear RNA export factor 2) is a critical player in the post-transcriptional regulation of gene expression, particularly in the export of mRNA from the nucleus to the cytoplasm. As a member of the NXF family, NXF2 bears significant similarity to its counterpart NXF1, but it shows distinct roles in RNA metabolism and cellular processes. Understanding NXF2 has gained prominence due to its implications in various cellular functions, including stress responses and the interplay between nuclear transport and viral replication. Recent studies have highlighted its involvement in the export of a subset of mRNAs, particularly those associated with neuronal function and differentiation, thus linking NXF2 to neurodevelopmental processes. The recombinant protein production of NXF2 allows for in-depth biochemical characterization and functional studies, aiding in the elucidation of its mechanism of action and interactions with other cellular factors. Furthermore, the exploration of NXF2 dysfunction has potential implications in understanding various diseases, including cancer and neurodegenerative disorders, underscoring the need for detailed investigations into its structure and functional dynamics. Overall, the research on NXF2 and its recombinant protein serves as a pivotal area for understanding the complex regulatory networks involved in RNA export and cellular homeostasis.
