Analytical Data
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基因名
SH3BGRL
- Application
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别名
SH3BGRL;Adapter SH3BGRL
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75368
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表达区间
1-114aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMVIRVY IASSSGSTAI KKKQQDVLGF LEANKIGFEE KDIAANEENR KWMRENVPEN SRPATGYPLP PQIFNESQYR GDYDAFFEAR ENNAVYAFLG LTAPPGSKEA EVQAKQQA
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SH3BGRL (SH3 Domain Binding Glutamic Acid-Rich Locus) is a protein that plays a critical role in various cellular processes, including cell signaling, proliferation, and differentiation. Its interactions with SH3 domains of other proteins suggest it may act as a scaffold or regulatory molecule in signal transduction pathways. Research into SH3BGRL has gained momentum due to its potential implications in human health, particularly in cancer biology and neurodegenerative diseases. Abnormal expression of SH3BGRL has been linked to tumorigenesis, making it a candidate for targeted therapies or biomarkers in specific cancers. Moreover, its involvement in neuronal signaling highlights its relevance in understanding neurological disorders. Investigating the structural and functional properties of SH3BGRL through recombinant protein techniques provides insights into its role in cellular functions and interactions with other signaling molecules. This research not only facilitates a better understanding of the fundamental biology of SH3BGRL but also paves the way for therapeutic advancements in diseases where SH3BGRL's dysregulation has been identified. Thus, the recombinant expression and characterization of SH3BGRL is crucial for unraveling its biological significance and potential exploitation in biomedical applications.
