Analytical Data
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Gene name
AP1m1
- Application
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Alternative Names
AP1m1；CLTNM；AP-1 complex subunit mu-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXS5
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Expression Region
2-423aa
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AA Sequence
SASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP ATVTNAVSWR SEGIKYRKNE VFLDVIESVN LLVSANGNVL RSEIVGSIKM RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ CVRLSRFEND RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMIKAKSQ FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSIKSFPG GKEYLMRAHF GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK SGYQALPWVR YITQNGDYQL RTQ
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Molecular Weight
48.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP1M1, or adaptor protein complex 1 mu 1 subunit, plays a critical role in cellular transport processes, particularly in the trafficking of proteins between the trans-Golgi network and endosomes. It is part of the AP-1 complex, which is essential for the sorting and delivery of proteins to their appropriate destinations within cells. Dysregulation of AP1M1 has been linked to various diseases, including neurodegenerative disorders and cancer, highlighting its significance in maintaining cellular homeostasis. Recent studies have focused on the structural and functional characterization of AP1M1, utilizing techniques like cryo-electron microscopy and X-ray crystallography to elucidate its role in clathrin-mediated endocytosis. Understanding the molecular mechanisms governing AP1M1 function can provide insights into the pathogenesis of related diseases and pave the way for the development of targeted therapies. As researchers continue to explore the intricacies of protein transport and sorting, AP1M1 remains a key focus for advancing our knowledge of cellular dynamics and developing therapeutic strategies for its associated pathologies.
