Analytical Data
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Gene name
SERPING1
- Application
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Alternative Names
SERPING1;C1IN;C1NH;Plasma protease C1 inhibitor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05155
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Expression Region
23-500aa
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AA Sequence
NPNATSSSSQ DPESLQDRGE GKVATTVISK MLFVEPILEV SSLPTTNSTT NSATKITANT TDEPTTQPTT EPTTQPTIQP TQPTTQLPTD SPTQPTTGSF CPGPVTLCSD LESHSTEAVL GDALVDFSLK LYHAFSAMKK VETNMAFSPF SIASLLTQVL LGAGENTKTN LESILSYPKD FTCVHQALKG FTTKGVTSVS QIFHSPDLAI RDTFVNASRT LYSSSPRVLS NNSDANLELI NTWVAKNTNN KISRLLDSLP SDTRLVLLNA IYLSAKWKTT FDPKKTRMEP FHFKNSVIKV PMMNSKKYPV AHFIDQTLKA KVGQLQLSHN LSLVILVPQN LKHRLEDMEQ ALSPSVFKAI MEKLEMSKFQ PTLLTLPRIK VTTSQDMLSI MEKLEFFDFS YDLNLCGLTE DPDLQVSAMQ HQTVLELTET GVEAAAASAI SVARTLLVFE VQQPFLFVLW DQQHKFPVFM GRVYDPRA
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Molecular Weight
53 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SERPING1, also known as C1 inhibitor, is a critical protein that regulates the complement and contact activation pathways of the immune system. Its primary role is to inhibit serine proteases, particularly those involved in the kallikrein-kinin system, which is essential for maintaining vascular homeostasis and modulating inflammation. Deficiencies or dysfunctions in SERPING1 are implicated in hereditary angioedema (HAE), a genetic condition characterized by recurrent episodes of severe swelling and potentially life-threatening complications. The study of recombinant SERPING1 has gained significant attention as it offers a promising therapeutic avenue for managing HAE and other complement-related disorders. Researchers are focused on optimizing the production and characterization of recombinant SERPING1 to improve its stability, efficacy, and safety for clinical use. By understanding the structure-function relationships of SERPING1, scientists aim to develop targeted therapies that can mitigate the effects of its deficiencies and enhance the body’s ability to regulate immune responses. Furthermore, the exploration of recombinant SERPING1 extends beyond HAE, as its modulation could have implications for various inflammatory diseases and conditions associated with dysregulated complement system activity. Overall, the research on SERPING1 and its recombinant forms holds potential for significant advancements in both therapeutic strategies and our understanding of immune regulation.
