Analytical Data
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Gene name
gABRa6
- Application
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Alternative Names
gABRa6；Gamma-aminobutyric acid receptor subunit alpha-6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16445
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Expression Region
1-453aa
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AA Sequence
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
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Molecular Weight
51 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of the gABRa6 recombinant protein has gained attention due to its significant role in the gamma-aminobutyric acid (GABA) receptor system, a critical component of the central nervous system that regulates neuronal excitability. GABRA6, a subunit of the GABA receptor, is involved in forming various receptor isoforms that influence inhibitory neurotransmission. Mutations or dysregulation of GABRA6 have been associated with several neurological disorders, including anxiety disorders, epilepsy, and autism spectrum disorders. Research focusing on gABRa6 recombinant protein aims to elucidate its structural and functional properties, paving the way for potential therapeutic interventions. By producing this protein through recombinant DNA technology, researchers can analyze its interactions, pharmacological profiles, and role in receptor assembly and function, enhancing our understanding of receptor signaling pathways. Such insights may lead to the development of targeted treatments that modulate GABAergic transmission, thereby offering hope for patients suffering from GABA-related pathologies. Overall, the ongoing research into gABRa6 represents a promising frontier in neuroscience, with implications for drug discovery and the advancement of precision medicine strategies.
