Analytical Data
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基因名
gABRa6
- Application
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别名
gABRa6；Gamma-aminobutyric acid receptor subunit alpha-6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16445
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表达区间
1-453aa
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氨基酸序列
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
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分子量
51 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the gABRa6 recombinant protein has gained attention due to its significant role in the gamma-aminobutyric acid (GABA) receptor system, a critical component of the central nervous system that regulates neuronal excitability. GABRA6, a subunit of the GABA receptor, is involved in forming various receptor isoforms that influence inhibitory neurotransmission. Mutations or dysregulation of GABRA6 have been associated with several neurological disorders, including anxiety disorders, epilepsy, and autism spectrum disorders. Research focusing on gABRa6 recombinant protein aims to elucidate its structural and functional properties, paving the way for potential therapeutic interventions. By producing this protein through recombinant DNA technology, researchers can analyze its interactions, pharmacological profiles, and role in receptor assembly and function, enhancing our understanding of receptor signaling pathways. Such insights may lead to the development of targeted treatments that modulate GABAergic transmission, thereby offering hope for patients suffering from GABA-related pathologies. Overall, the ongoing research into gABRa6 represents a promising frontier in neuroscience, with implications for drug discovery and the advancement of precision medicine strategies.
