Analytical Data
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基因名
NLRP2
- Application
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别名
CLR19.9; FLJ20510; Leucine rich repeat and PYD containing protein 2; LRR and PYD domains-containing protein 2; NACHT; NACHT domain; NACHT leucine rich repeat and PYD containing 2; NACHT LRR and PYD domains containing protein 2; NALP2; NALP2_HUMAN; NBS1; NLR family pyrin domain containing 2; NLRP2; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN containing APAF1 like protein2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NX02
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表达区间
1-1062 aa
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氨基酸序列
MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI
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分子量
146.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NLRP2 (NACHT, LRR, and PYD domains-containing protein 2) is a member of the NLR (NOD-like receptor) family, which plays a crucial role in the innate immune system by sensing cellular stress and pathogen-associated patterns. The relevance of NLRP2 in immune responses, inflammation, and developmental processes has garnered increasing attention in recent research. However, the specific biological functions and mechanisms of NLRP2 remain poorly understood, primarily due to the lack of available structural and functional studies. Recombinant NLRP2 protein has emerged as a valuable tool for investigating its interactions, post-translational modifications, and signaling pathways. Generating a stable and functional recombinant NLRP2 protein can facilitate elucidating its role in immunological processes and its potential implications in autoimmune diseases, cancer, and developmental disorders. Furthermore, studies using recombinant NLRP2 will contribute to our understanding of NLRP2's regulation within the NLR family and its unique functions compared to other NLR members. As research continues to uncover the complexities of immune responses, the detailed characterization of NLRP2 through recombinant protein studies will provide critical insights into its biological significance and therapeutic potential.
