Analytical Data
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Gene name
NKX6-3
- Application
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Alternative Names
FLJ25169; Homeobox protein Nkx 6.3; Homeobox protein Nkx-6.3; NK6 homeobox 3; NKX6-3; NKX6.3; NKX63; NKX63_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A6NJ46
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Expression Region
1-265 aa
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AA Sequence
MESNLQGTFL LNNTPLAQFP EMKAPVCQYS VQNSFYKLSP PGLGPQLAAG TPHGITDILS RPVAAPNNSL LSGYPHVAGF GGLSSQGVYY SPQVGNFSKA GNEYPTRTRN CWADTGQDWR GGRQCSNTPD PLSDSIHKKK HTRPTFTGHQ IFALEKTFEQ TKYLAGPERA RLAYSLGMTE SQVKVWFQNR RTKWRKKSAL EPSSSTPRAP GGAGAGAGGD RAPSENEDDE YNKPLDPDSD DEKIRLLLRK HRAAFSVLSL GAHSV
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Molecular Weight
28.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NKX6-3 is a member of the NKX family of homeobox transcription factors, which play crucial roles in the development and function of various tissues, particularly in the pancreas and neural systems. Research has shown that NKX6-3 is involved in regulating gene expression crucial for pancreatic development, including the differentiation of endocrine and acinar cells. Additionally, it has been implicated in the modulation of cell signaling pathways that affect cellular growth and survival. Given the critical functions of NKX6-3 in endocrine biology, researchers are investigating its potential roles in diabetes and other metabolic disorders, where pancreatic dysfunction is a key feature. The production and study of recombinant NKX6-3 protein enable scientists to explore its molecular properties and interactions, fundamental for understanding its role in health and disease. This recombinant protein serves as a valuable tool for elucidating the mechanisms through which NKX6-3 influences pancreatic development and function, potentially leading to new therapeutic strategies for metabolic diseases.
